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About Us
Advancing drug development through expertise
and innovation in nonclinical research.
CENTER FOR NON-CLINICAL DEVELOPMENT
Welcome.
Despite the extraordinary progress in drug development, development failures remain common. It is especially unfortunate when a program fails because predictable and manageable issues were not addressed with sufficient experience or technical insight.

Drug development is often called a failure-prone industry, which makes effective attrition management essential. In toxicology, risk management is itself a core capability of drug development because toxicity must be anticipated and managed through multidisciplinary knowledge and experience.

CND (Center for Non-clinical Development) originated as the name used during a Ministry of Trade, Industry and Energy project to establish and provide a predictive assessment platform for reducing drug-development failure. Although the project has concluded, we continue its sustainable educational activities on a voluntary basis.

Our laboratory works with drug developers to resolve and manage diverse toxicity issues, improve the probability of success, and share the resulting knowledge and experience. We welcome your interest and participation as we work to advance nonclinical toxicology capabilities in Korea.
Thank you.
Professor Woo-Chan Son
Asan Medical Center Woo-Chan Son
CURRICULUM VITAE
Curriculum Vitae & Research

Curriculum Vitae

  • DVM and PhD, specializing in veterinary medicine and toxicologic pathology
  • Professor of Pathology, Asan Medical Center / Experimental and Toxicologic Pathology
  • Training in experimental pathology, Hannover Medical School, Germany
  • Principal Research Scientist in toxicologic pathology, LG Life Sciences — 10 years
  • Senior Pathologist, Huntingdon Life Sciences (now Labcorp), United Kingdom — 10 years
  • Asan Medical Center and University of Ulsan College of Medicine — 16 years

Professional Qualifications & Activities

  • Fellow of International Academy of Toxicologic Pathology (FIATP)
  • Former Associate Editor, Toxicologic Pathology
  • Member, Central Pharmaceutical Affairs Council, Ministry of Food and Drug Safety

Awards

  • Ministerial Commendation, Ministry of Trade, Industry and Energy, and other honors

Consulting Experience

  • Consulting for numerous organizations in Korea, the United States, Europe, Japan and China
  • Extensive annual and cumulative consulting engagements and collaborations

Patents

  1. Recombinant vaccinia virus expressing IL-12 and an immune-checkpoint inhibitor, and uses thereof 2024.08.19
  2. Novel vaccinia virus variant with increased extracellular enveloped-virus production 2022.12.29
  3. Novel vaccinia virus variant with increased extracellular enveloped-virus production 2022.12.28
  4. Recombinant vaccinia virus expressing IL-12, and uses thereof 2022.12.07
  5. Recombinant vaccinia virus expressing IL-12, and uses thereof 2022.12.06
  6. Vaccinia virus variant with increased extracellular enveloped-virus production 2021.12.29
  7. Construction and characterization of an IHD-strain vaccinia viral vector replacing B8R with murine interleukin-12 (IL-12) 2021.12.07
  8. Training methods, programs and systems for an AI-based comet-assay analysis model, and analysis methods using the same 2020.03.18

Selected Publications

120+ publications in the past five years
Research in toxicologic pathology and nonclinical development
Select a title to open its DOI or official publication page.
  1. Deep learning based method for grading histopathological liver fibrosis in rodent models of metabolic dysfunction associated steatohepatitisFrontiers in Medicine, 2025;12:1629036
  2. Tie2 activator 4E2 ameliorates diabetic nephropathy and synergizes with dapagliflozin in a mouse modelKorean Journal of Physiology & Pharmacology, 2025;29(5):613–623
  3. Toxicity and efficacy study of a combination of two retinoic acids in an ApoE knockout mouse model of atherosclerosisKorean Journal of Physiology & Pharmacology, 2025;29(2):179–189
  4. Enhanced productivity and comet plaque formation in a newly isolated clone of the Vaccinia virus IHD strainSSRN Preprint, 2025
  5. Improved safety of chimeric antigen receptor T cells indirectly targeting antigens via switchable adaptersNature Communications, 2024;15:9917
  6. Anti-4-1BB×PD-L1 Bispecific Antibody Reinvigorates Tumor-Specific Exhausted CD8+ T Cells and Enhances the Efficacy of Anti-PD-1 BlockadeClinical Cancer Research, 2024;30(18):4155–4166
  7. Fast formation and maturation enhancement of human liver organoids using a liver-organoid-on-a-chipFrontiers in Cell and Developmental Biology, 2024
  8. Toxicology and safety study of L-tryptophan and its impurities for use in swineJournal of Applied Toxicology, 2024;44(8):1153–1165
  9. Two-year carcinogenicity study of a novel plasticizer, bis(2-ethylhexyl) cyclohexane-1,4-dicarboxylate (Eco-DEHCH), by oral diet in Han Wistar ratsRegulatory Toxicology and Pharmacology, 2024;151:105664
  10. Toxicology and safety study of L-tryptophan and its impurities for use in broiler feedJournal of Applied Toxicology, 2024
  11. Combination of PD-1 Checkpoint Blockade and Botulinum Toxin Type A1 Improves Antitumor Responses in Mouse Tumor Models of Melanoma and Colon CarcinomaImmunological Investigations, 2023;52(6):749–766
  12. Safety concerns regarding impurities in L-Tryptophan associated with eosinophilia myalgia syndromeFood and Chemical Toxicology, 2023;179:113946
  13. Carcinogenicity assessment of tegoprazan in Sprague-Dawley rats and ICR miceRegulatory Toxicology and Pharmacology, 2023;142:105424
  14. Evaluation of the 52-week chronic toxicity of a novel phthalate-free plasticizer, Eco-DEHCH, in Han Wistar ratsFood and Chemical Toxicology, 2023;176:113809
  15. Safety evaluation of dried L-tryptophan fermentation product in Sprague-Dawley ratsToxicology Reports, 2022;9:1099–1113
  16. A Selective Adenosine A3 Receptor Antagonist, HL3501, Has Therapeutic Potential in Preclinical Liver and Renal Fibrosis ModelsIn Vivo, 2022;36:2186–2193
  17. HL3501, a Novel Selective A3 Adenosine Receptor Antagonist, Lowers Intraocular Pressure in Animal Glaucoma ModelsTranslational Vision Science & Technology, 2022
  18. CKD-506: A novel HDAC6-selective inhibitor that exerts therapeutic effects in a rodent model of multiple sclerosisScientific Reports, 2021
  19. Toxicological profile of bisphenol F via comprehensive and extensive toxicity evaluations following dermal exposureJournal of Toxicology and Environmental Health, Part A, 2021
  20. M-134, a novel HDAC6-selective inhibitor, markedly improved arthritic severity in a rodent model of rheumatoid arthritis when combined with tofacitinibPharmacological Reports, 2021;73(1):185–201
  21. Comparative Analyses of Inflammatory Response and Tissue Integration of 14 Hyaluronic Acid-Based Fillers in Mini PigsClinical, Cosmetic and Investigational Dermatology, 2021;14:765–778
  22. Predicting Successes and Failures of Clinical Trials With Outer Product-Based Convolutional Neural NetworkFrontiers in Pharmacology, 2021;12:670670
  23. Comparative Analysis of Hyaluronidase-Mediated Degradation Among Seven Hyaluronic Acid Fillers in Hairless MiceClinical, Cosmetic and Investigational Dermatology, 2021;14:241–248
  24. Predicting successes and failures of clinical trials with an ensemble LS-SVRmedRxiv Preprint, 2020
  25. PKM2 in Canine Mammary Tumors: Parallels to Human Breast CancerComparative Medicine, 2020;70(4):349–354
  26. Dataset and Deep Learning Baseline Method for Comet Segmentation for Comet Assay Image AnalysisScientific Reports, 2020
  27. Association between ARID2 and RAS-MAPK pathway in intellectual disability and short statureJournal of Medical Genetics, 2021;58(11):767–777
  28. Identifying Stabilin-1 and Stabilin-2 Double Knockouts in Reproduction and Placentation: A Descriptive StudyInternational Journal of Molecular Sciences, 2020;21(19)
  29. Sappanone A Prevents Left Ventricular Dysfunction in a Rat Myocardial Ischemia Reperfusion Injury ModelInternational Journal of Molecular Sciences, 2020
  30. Use of 3D Human Liver Organoids to Predict Drug-Induced PhospholipidosisInternational Journal of Molecular Sciences, 2020
  31. Metformin Alleviates Left Ventricular Diastolic Dysfunction in a Rat Myocardial Ischemia Reperfusion Injury ModelInternational Journal of Molecular Sciences, 2020